Yersinia type III secretion: send in the effectors
نویسندگان
چکیده
Pathogenic Yersinia spp ( Yersinia pestis , Yersinia pseudotuberculosis , and Yersinia enterocolitica ) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells’ response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis and inflammation.
منابع مشابه
Yersinia enterocolitica type III secretion-translocation system: channel formation by secreted Yops.
'Type III secretion' allows extracellular adherent bacteria to inject bacterial effector proteins into the cytosol of their animal or plant host cells. In the archetypal Yersinia system the secreted proteins are called Yops. Some of them are intracellular effectors, while YopB and YopD have been shown by genetic analyses to be dedicated to the translocation of these effectors. Here, the secreti...
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Yersinia uses a type III secretion system (TTSS) to deliver six effector proteins into host cells. These six proteins harbor distinct activities that are mimicries of host functions but often have acquired unique biochemical features. The host targets for these effectors appear to be limited to a few key signaling components such as G proteins and kinases, whereas their models of action are div...
متن کاملYersinia type III secretion
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis a...
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Type III secretion systems harbored by several Gram-negative bacteria are often used to deliver host-modulating effectors into infected eukaryotic cells. About 20 core proteins are needed for assembly of a secretion apparatus. Several of these proteins are genetically and functionally conserved in type III secretion systems of bacteria associated with invertebrate or vertebrate hosts. In the Ys...
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Yersinia pseudotuberculosis is a Gram-negative bacterial pathogen. Virulence in Y. pseudotuberculosis requires the plasmid-encoded Ysc type III secretion system (T3SS), which functions to translocate a set of effectors called Yops into infected host cells. The effectors function to antagonize phagocytosis (e.g., YopH) or to induce apoptosis (YopJ) in macrophages infected with Y. pseudotuberculo...
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